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Eupraxia Pharmaceuticals Inc.: A Single-Dose, Locally Delivered Steroid Approach to Eosinophilic Esophagitis Entering a Randomized Readout

Maker Capital Research2026-10-2411 min read
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Clinical-Stage Gastroenterology TSX: EPRX | Nasdaq: EPRX

52-week remission
64%
9 of 14, open-label (Sep 30, 2026)
Phase 2b enrolled
120
target reached Oct 12, 2026
Cash and equivalents
US$52.4M
plus US$81.2M short-term investments, Jun 30, 2026
Phase 2b interim data
Dec 2026
Company expectation (Oct 15, 2026)

Three things to know

  1. In open-label RESOLVE Cohorts 5 to 9, the Company reported pooled clinical remission of 64% (9 of 14) at 52 weeks on September 30, 2026. These are small, uncontrolled cohorts without a placebo group.
  2. On October 15, 2026 the Company reported that its 120th Phase 2b patient was enrolled and treated on October 12, 2026, and it expects interim data on the first 60 patients to reach six months in December 2026.
  3. Eupraxia held US$52.4 million in cash and cash equivalents and US$81.2 million in short-term investments at June 30, 2026, and anticipates that existing cash reserves will fund the Company into the second half of 2028 (release, August 11, 2026).

Company Profile

Eupraxia Pharmaceuticals Inc. (TSX: EPRX | Nasdaq: EPRX) is a clinical-stage biotechnology company focused on locally delivered, extended-release products built on its proprietary, polymer-based Diffusphere micro-sphere technology.

The Company's lead program is EP-104GI, which uses extended-release fluticasone propionate and is administered as an injection into the esophageal wall for the treatment of eosinophilic esophagitis (EoE). The RESOLVE trial combines an open-label Phase 1b/2a dose-escalation portion with a randomized, placebo-controlled Phase 2b portion.

The Company was incorporated in Alberta on May 12, 2011. On July 13, 2026, it reported moving its operations from Victoria, British Columbia, to hubs in Vancouver and Seattle. On September 8, 2026, its common shares commenced trading on the Nasdaq Global Select Market, having previously been listed on the Nasdaq Capital Market. The Company reports in U.S. dollars, and figures below are in U.S. dollars unless marked C$.

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